Vitamin D Study

Objective

To reach Vitamin D's ideal range of 50-80 ng/mL and compare necessary doses across different genetic variants of the VDR gene.

Description

Dr. John Cannell of the Vitamin D Council suggests that you take 1,000 IU per 25 pounds of body weight as a starting vitamin D dosage. A person who weighs 150 pounds, for instance, would take 6,000 IU per day.

Do this for at least eight weeks, and then get a vitamin D test. Perhaps this dose will put you in the ideal range, but there's no guarantee, since we are all different. The idea is to hopefully get somewhere in the ballpark and then tweak your daily dose from there.

If your blood levels are still low, Dr. Cannell estimates that each 1,000 IU increase in your vitamin D dosage will produce about a 10 ng/ml increase in the vitamin D blood level. For example, if you have been taking 5,000 IU per day for 8+ weeks, and your results come back at 40 ng/ml, you would want to increase your dose to at least 7,000 IU to achieve a minimum of 60 ng/ml.

Inclusion Criteria

Since vitamin D precursors require cholesterol for conversion into the hormone-like vitamin, without adequate sun exposure vitamin D precursors can turn into cholesterol instead of the vitamin. Vitamin D can also cause calcium to be released from bones- hypercalcemia. cannot participate if history or genetics increases risk. Also any underlying kidney disease preclude participants.
Take vitamin D3 supplements, obtain a 25-hydroxyvitamin D test, record results.

Vitamin D, 25-Hydroxy Blood Test

Discussion

leumine

leumine joined as a data participant.

evafay

evafay joined as a data participant.

Lameiga

Lameiga joined as a data participant.

timdang

timdang joined as a discussion participant.

skyline

skyline joined as a data participant.

drdelorenzo

drdelorenzo joined as a discussion participant.

bluenomad

bluenomad joined as a data participant.

Hereward

Hereward joined as a data participant.

wellthcare

wellthcare joined as a discussion participant.

wellthcare

wellthcare When talking of supplements, which brand or are they all the same??? Is timing and dosing important? If D3 supplementation is truly meant to be effective do we need to understand their dosing and regimen along the lines of taking any therapeutic intervention?

wreinhardt

wreinhardt good questions. I at least have been treating different brands the same, but I did notice there are new products offering single vitamin d doses combined with magnesium and calcium so I might try that.

sam

sam joined as a data participant.

nikolay

nikolay joined as a data participant.

SydneyBennet

SydneyBennet joined as a discussion participant.

jeffk8900

jeffk8900 joined as a data participant.

jeffk8900

jeffk8900 I had a measure of 11 ng/mL 12/29/10. Started supplementing around 5000 units and had a 39.5 ng/mL on 5/16/11. Bumped up supplementation range between 5000-10000. Need to get standardized supp levels however.

EriGentry

EriGentry Wow! Were you taking the 5k iu every day? And did you notice any changes before/after?

jpabello

jpabello joined as a data participant.

jpabello

jpabello My level was at 34.5 ng/ml back on 12/14/2010, while taking 2000IU per day after a 2 week vacation in Argentina (summertime there). I just had another blood test last week and results should come back in about 2 weeks.

EriGentry

EriGentry Will, how's your D doing? I just finished my course of 4-6k IU/day but haven't done a followup test. Is your level up??

wreinhardt

wreinhardt Will test again next week

wreinhardt

wreinhardt After 8 weeks of daily 2400 IU I reached 39.8 ng/mL from my baseline of 29. It took more than expected so I will now take 4800 IU to see if I can reach 50.

EriGentry

EriGentry Any idea what happens when Vitamin D is too high? (A friend tested at 86 so want to understand the consequences.)

wreinhardt

wreinhardt it looks like a good indicator of overdose may by a metallic taste in the mouth. check out http://www.drugs.com/mtm/vitamin-d.html

herbaldoc

herbaldoc joined as a data participant.

herbaldoc

herbaldoc Have been taking 5000iu for 6+ months. 4 months in, on Jan 11, 2011 my 25-OH was 43.1ng/ml. Since my testing up to this point was for personal study, I have no baseline. Will post next set of tests soon!

wreinhardt

wreinhardt great info, keep tracking and let us know. thanks

EriGentry

EriGentry Tim Ferriss describes his experience with Vitamin D dosing and testing on pp 513-514 of 4HB: Baseline from first blood test: 32 ng/ml. Second test on 8/30/09 (after two months of taking 1,000 IU/day and 20 min sun exposure daily): 35 ng/ml. Third test five weeks later (after increasing intake to 7,200 IU/day): 59 ng/ml

EriGentry

EriGentry The goal is to get to at least 50 ng/ml, the level at which peak athletic performance happens. 50 is hard to achieve -- it takes persistence full-body exposure to summer sun or supplementation. Tim recommends getting testing first, to establish a baseline, then - if your level is below 50 - taking 6,000 - 10,000 IU/day for 4 weeks. This is very close to what my naturopath recommends: 6k IU/day for a month, then 1k IU/day maintenance. She said Californians have surprisingly low levels of D, despite being in a sunny state. The supplementation helped patients have a better sense of well being. For the record, I'm 2 weeks through taking 4k IU/day D3 and had a baseline of 27. I was not keen to take so much but, after hearing positive reports from my doc, I decided to give it a go.

wreinhardt

wreinhardt Starting with a baseline of 29, I am taking 2000 for four weeks, getting another test, and most likely 4000 for four more.

wreinhardt

wreinhardt Good point, but because D is fat-soluble and due to varying amounts in multivitamins that people may already be taking it might not be ideal to aim for a true washout and maybe just a starting figure. Thoughts?

gbiggers

gbiggers Yeah, not washout, but starting figure.

wreinhardt

wreinhardt yes, I haven't taken any supplements for 3 months. Will get a test and then start soon.

gbiggers

gbiggers wreinhardt-- would you consider making the study title a little more specific? Maybe something like this: "Vitamin D Supplementats and VDR Gene"

wreinhardt

wreinhardt may want to consider other genes as well, not sure

gbiggers

gbiggers I happen to have just been tested for Vitamin D (which was ordered before this study was posted-- serendipitous timing!). Blood test on 2011-03-07 showed Vitamin D (25 Hydroxy) concentration of 18.0 ng/ml -- below the National Osteoporosis Foundation recommendation of at least 30 ng/ml.

derekja

derekja joined as a data participant.

see all 4 comments
derekja

derekja Looking forward to it. I have a lab result of 67 nmol/L from last year and currently supplement at 2000 IU per day. report out a couple of days ago makes this really timely! http://www.eurekalert.org/pub_releases/2011-02/uoc--hvd022211.php

derekja

derekja ah, I better check on the kidney status before putting myself in as a participant. I have a propensity to form calcium oxylate kidney stones, but kidney function is at normal levels. OK to join?

wreinhardt

wreinhardt have you done a kidney function blood test (creatine, BUN, etc)?

derekja

derekja yes, that's the basis for the assertion that kidney function is normal. Borderline normal, but normal. EGFR of 61 last test.

gbiggers

gbiggers Cool study. Should people get a baseline blood test before doing the supplement?

EriGentry

EriGentry joined as a data participant.

gbiggers

gbiggers joined as a data participant.

Show All Posts…