Vitamin D Study
ObjectiveTo reach Vitamin D's ideal range of 50-80 ng/mL and compare necessary doses across different genetic variants of the VDR gene.
DescriptionDr. John Cannell of the Vitamin D Council suggests that you take 1,000 IU per 25 pounds of body weight as a starting vitamin D dosage. A person who weighs 150 pounds, for instance, would take 6,000 IU per day.
Do this for at least eight weeks, and then get a vitamin D test. Perhaps this dose will put you in the ideal range, but there's no guarantee, since we are all different. The idea is to hopefully get somewhere in the ballpark and then tweak your daily dose from there.
If your blood levels are still low, Dr. Cannell estimates that each 1,000 IU increase in your vitamin D dosage will produce about a 10 ng/ml increase in the vitamin D blood level. For example, if you have been taking 5,000 IU per day for 8+ weeks, and your results come back at 40 ng/ml, you would want to increase your dose to at least 7,000 IU to achieve a minimum of 60 ng/ml.
Inclusion CriteriaSince vitamin D precursors require cholesterol for conversion into the hormone-like vitamin, without adequate sun exposure vitamin D precursors can turn into cholesterol instead of the vitamin. Vitamin D can also cause calcium to be released from bones- hypercalcemia. cannot participate if history or genetics increases risk. Also any underlying kidney disease preclude participants.
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EriGentry Will, how's your D doing? I just finished my course of 4-6k IU/day but haven't done a followup test. Is your level up??
EriGentry Any idea what happens when Vitamin D is too high? (A friend tested at 86 so want to understand the consequences.)
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EriGentry Tim Ferriss describes his experience with Vitamin D dosing and testing on pp 513-514 of 4HB: Baseline from first blood test: 32 ng/ml. Second test on 8/30/09 (after two months of taking 1,000 IU/day and 20 min sun exposure daily): 35 ng/ml. Third test five weeks later (after increasing intake to 7,200 IU/day): 59 ng/ml
wreinhardt Good point, but because D is fat-soluble and due to varying amounts in multivitamins that people may already be taking it might not be ideal to aim for a true washout and maybe just a starting figure. Thoughts?
gbiggers wreinhardt-- would you consider making the study title a little more specific? Maybe something like this: "Vitamin D Supplementats and VDR Gene"
gbiggers I happen to have just been tested for Vitamin D (which was ordered before this study was posted-- serendipitous timing!). Blood test on 2011-03-07 showed Vitamin D (25 Hydroxy) concentration of 18.0 ng/ml -- below the National Osteoporosis Foundation recommendation of at least 30 ng/ml.
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gbiggers Cool study. Should people get a baseline blood test before doing the supplement?