Vitamin B-9 and MTHFR variants
ObjectiveDo common variations in the MTHFR gene keep vitamin B from working? Can a group of ordinary people come together to find out? And maybe find a treatment?
DescriptionIn the MTHFR gene (methylenetetrahydrofolate reductase), 2 small variations in DNA (SNPs rs1801133/C677T & rs1801131/A1298C) keep vitamin B9 (or folic acid) from being metabolized into its active form (folate).
Without this form of vitamin B, homocysteine may accumulate. This may lead to nutritional deficiencies and symptoms associated with diabetes complications, including vascular damage and nerve damage. This is also associated with blood clots and pregnancy loss.
Up to 60% of people may have some form of MTHFR mutation.
We aim to:
- Find people with MTHFR mutations - by collecting genotype data from volunteers who have used genetic testing services.
- Try simple interventions - like special vitamin B supplements available over-the-counter.
- See if they work - by asking participants to share results from blood tests performed at commercial labs.
But we can. The tools to do this -- to look at genomic information, to measure treatment results, and to analyze the data -- are now cheap or free.
All we need are concerned people who care enough to help. Want to answer this question? Want to help build community and tools that let people take personal charge of their health?
Inclusion CriteriaPlease no participants with known vitamin B deficiences, anyone not able to follow the outlined vitamin protocol, or anyone who might have health problems related to high homocysteine levels.
Day 1: Submit your personal genomic data on the specified MTHFR variants (handled on joining study)
Day 1: No Vitamin B supplements for 1 week
Day 8: Homocysteine Blood Test
- Check out the FAQ / informed consent (in development), and sign off on it.
- Submit data on MTHFR variants.
- Participate in at least 3 different 2 week trials, involving taking over-the-counter vitamins, then measuring homocysteine levels with a blood draw each time (blood tests cost about $70 each).
- Record your blood test data here
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There has been a lot of buzz on some of the Facebook support groups (LDN, Fibromyalgia, ME/CFS, MS, Lyme, etc.) about the fact that so many people are testing positive for MTHFR and also having these diseases. Would there be any chance of asking this question to the participants? I heard of one study for chronic Lyme that out of 200 subjects 198 had the mutation.
lisaacso joined as a data participant.
gotnospice Not sure if I should join, what genotypes for rs1801133 and 31 should I have to be able to join, or to have to worry?
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yaneverknow There is no way I could get my doctor to agree to this, so please remove me as a participant. I should have checked the requirements first.
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dschutz1 I am homozygous for rs1801131 (MTHFR A1298C), but negative for rs1801133 (MTHFR C677T) so I'm not sure if I qualify as a participant.
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